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Enzyme‐Responsive Delivery of Multiple Proteins with Spatiotemporal Control
Author(s) -
Zhu Suwei,
Nih Lina,
Carmichael S. Thomas,
Lu Yunfeng,
Segura Tatiana
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201500417
Subject(s) - enzyme , materials science , wound healing , nanotechnology , microbiology and biotechnology , biochemistry , biophysics , biology , immunology
Orchestrated biological materials such as enzymes and growth factors regulate the growth of tissues and organs. A chirality‐controlled, single‐protein technology is devised to tailor the spatiotemporally defined delivery of therapeutic proteins in response to natural enzymes present at wound sites. Sustained delivery of one protein and sequential delivery of two proteins are demonstrated for stroke and skin wound healing.