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Tissue: Scalable Units for Building Cardiac Tissue (Adv. Mater. 42/2014)
Author(s) -
Ye Xiaofeng,
Lu Liang,
Kolewe Martin E.,
Hearon Keith,
Fischer Kristin M.,
Coppeta Jonathan,
Freed Lisa E.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201470288
Subject(s) - materials science , elastomer , tissue engineering , biomedical engineering , in vivo , scalability , regenerative medicine , nanotechnology , composite material , stem cell , computer science , microbiology and biotechnology , medicine , biology , database
Scalable units for building cardiac tissue are created from biodegradable elastomeric polymers by L. E. Freed and co‐workers on page 7202. The multilayered scaffolds are fabricated by pairwise stacking of heart‐cell scaffolds with internal pore architectures and perfusable microvessels with rapidly degrading interfaces. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissue.