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Nanomedicine: Break‐up of Two‐Dimensional MnO 2 Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer (Adv. Mater. 41/2014)
Author(s) -
Chen Yu,
Ye Delai,
Wu Meiying,
Chen Hangrong,
Zhang Linlin,
Shi Jianlin,
Wang Lianzhou
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201470284
Subject(s) - nanomedicine , materials science , nanotechnology , in vivo , in vitro , cancer , tumor microenvironment , cancer research , biophysics , nanoparticle , tumor cells , chemistry , biochemistry , medicine , biology , microbiology and biotechnology
Exfoliated 2D MnO 2 nanosheets described by J. Shi, L. Wang, and co‐workers on page 7019, show a unique break‐up nature in mild acidic microenvironment of tumor tissues, which could substantially enhance the in vitro and in vivo performances of T 1 ‐weighted magnetic resonance imaging. Such a pH‐triggered break‐up nature can also promote the fast release of loaded anticancer drugs for concurrent pH‐responsive theranostics of cancer.