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Biomimetic Composites: Amyloid‐Hydroxyapatite Bone Biomimetic Composites (Adv. Mater. 20/2014)
Author(s) -
Li Chaoxu,
Born AnneKathrin,
Schweizer Thomas,
ZenobiWong Marcy,
Cerruti Marta,
Mezzenga Raffaele
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201470134
Subject(s) - materials science , filopodia , lamellipodium , composite number , composite material , osteoblast , adhesion , biomimetic synthesis , cytoskeleton , integrin , biomaterial , nanotechnology , cell , in vitro , biochemistry , chemistry , organic chemistry , genetics , biology
On page 3207, R. Mezzenga and co‐workers demonstrate a human trabecular bone‐derived pre‐osteoblast cell growing and anchoring by filopodia and lamellipodia on top of a biomimetic bone hybrid composite made of lysozyme amyloid fibrils and hydroxyapatite platelets. Such spreading and focal adhesion complexes suggest a direct, integrin‐mediated connection of the cell cytoskeleton with the substrate.