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Gene‐Delivery Vectors: Viral Mimicking Ternary Polyplexes: A Reduction‐Controlled Hierarchical Unpacking Vector for Gene Delivery (Adv. Mater. 10/2014)
Author(s) -
He Yiyan,
Nie Yu,
Cheng Gang,
Xie Li,
Shen Youqing,
Gu Zhongwei
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201470067
Subject(s) - unpacking , materials science , ternary operation , gene delivery , diselenide , conjugated system , peg ratio , nanotechnology , hyaluronic acid , gene , biophysics , transfection , biology , genetics , computer science , polymer , selenium , finance , economics , metallurgy , composite material , philosophy , linguistics , programming language
Reduction‐controlled hierarchical unpacking is proposed by Z. Gu and co‐workers on page 1534 for the development of virus‐mimicking gene carriers. By combining a diselenide‐conjugated oligoethylenimine/DNA inner core with a disulfide‐modified hyaluronic acid shield, the resulting ternary polyplexes are designed to be stepwise triggered by the gradient glutathione (GSH) level both at the tumor site and inside the cells. The encouraging performance highlights the approach for more‐efficient gene delivery.