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Hydrogels: Biophysically Defined and Cytocompatible Covalently Adaptable Networks as Viscoelastic 3D Cell Culture Systems (Adv. Mater. 6/2014)
Author(s) -
McKin Daniel D.,
Domaille Dylan W.,
Cha Jennifer N.,
Anseth Kristi S.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201470033
Subject(s) - self healing hydrogels , covalent bond , materials science , ethylene glycol , viscoelasticity , hydrazone , cell encapsulation , nanotechnology , polymer , biophysics , cytoskeleton , chemical engineering , polymer chemistry , polymer science , cell , chemistry , composite material , organic chemistry , biochemistry , biology , engineering
A cell stressing a hydrazone‐crosslinked, step‐growth covalently adaptable poly(ethylene) glycol polymer network is shown in the image. Because of the dynamic nature of the hydrazone bonds, the stressed crosslinks yield to the forces applied by the cytoskeleton, allowing the cell to spread without perturbing the biophysical properties of the cellular microenvironment, as shown by Kristi S. Anseth and co‐workers on page 865.