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Biomedical Applications: Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo (Adv. Mater. 4/2014)
Author(s) -
Nelson Christopher E.,
Kim Arnold J.,
Adolph Elizabeth J.,
Gupta Mukesh K.,
Yu Fang,
Hocking Kyle M.,
Davidson Jeffrey M.,
Guelcher Scott A.,
Duvall Craig L.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201470023
Subject(s) - angiogenesis , scaffold , in vivo , neovascularization , biomaterial , materials science , regenerative medicine , nanotechnology , microbiology and biotechnology , biomedical engineering , cancer research , engineering , biology , stem cell
On page 607, C. L. Duvall and co‐workers detail a new technology for sustained, local delivery of siRNA. The authors apply this platform to manipulate activity of a pro‐angiogenic transcription factor, which orchestrates robust biomaterial scaffold neovascularization in vivo. This system may provide a superior approach to traditional pro‐angiogenic therapies and holds promise for broader application in regenerative medicine.