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Bioactive Gyroid Scaffolds Formed by Sacrificial Templating of Nanocellulose and Nanochitin Hydrogels as Instructive Platforms for Biomimetic Tissue Engineering
Author(s) -
TorresRendon Jose Guillermo,
Femmer Tim,
De Laporte Laura,
Tigges Thomas,
Rahimi Khosrow,
Gremse Felix,
Zafarnia Sara,
Lederle Wiltrud,
Ifuku Shinsuke,
Wessling Matthias,
Hardy John G.,
Walther Andreas
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201405873
Subject(s) - self healing hydrogels , gyroid , nanotechnology , chitin , tissue engineering , materials science , nanocellulose , biomaterial , cellulose , polymer science , biocompatible material , computer science , biomedical engineering , engineering , polymer chemistry , chemical engineering , composite material , chitosan , copolymer , polymer
A sacrificial templating process using lithographically printed minimal surface structures allows complex de novo geometries of delicate hydrogel materials. The hydrogel scaffolds based on cellulose and chitin nanofibrils show differences in terms of attachment of human mesenchymal stem cells, and allow their differentiation into osteogenic outcomes. The approach here serves as a first example toward designer hydrogel scaffolds viable for biomimetic tissue engineering.