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Self‐Organizing Large‐Scale Extracellular‐Matrix Protein Networks
Author(s) -
Ahn Seungkuk,
Deravi Leila F.,
Park SungJin,
Dabiri Borna E.,
Kim JoonSeop,
Parker Kevin Kit,
Shin Kwanwoo
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201405556
Subject(s) - materials science , extracellular matrix , scale (ratio) , matrix (chemical analysis) , nanotechnology , composite material , biology , microbiology and biotechnology , physics , quantum mechanics
Spontaneous, highly ordered large‐scale fibronectin networks driven by electrostatic polymer patterns are fabricated, and these precisely controlled protein connections are demonstrated. It is examined whether this scheme, universal to various fibrillar extracellular matrix proteins beyond fibronectin, collagen, and laminin, can be self‐organized. These data reveal a novel bottom‐up method to form anisotropic, free‐standing protein networks to be used as flexible, transferrable substrates for cardiac and neuronal tissue engineering.