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Intelligent MnO 2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH‐/H 2 O 2 ‐Responsive UCL Imaging and Oxygen‐Elevated Synergetic Therapy
Author(s) -
Fan Wenpei,
Bu Wenbo,
Shen Bo,
He Qianjun,
Cui Zhaowen,
Liu Yanyan,
Zheng Xiangpeng,
Zhao Kuaile,
Shi Jianlin
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201405141
Subject(s) - photon upconversion , materials science , nanomaterials , photodynamic therapy , nanotechnology , oxygen , luminescence , irradiation , chemical engineering , optoelectronics , chemistry , organic chemistry , physics , nuclear physics , engineering
Intelligent 2D theranostic nanomaterials are successfully designed based on pH‐/H 2 O 2 ‐responsive MnO 2 nanosheets anchored with upconversion nanoprobes. They react with acidic H 2 O 2 to generate sufficient oxygen for enhancing the synergetic radio/photodynamic therapy efficacy upon NIR light/X‐ray irradiation and recover/enhance the upconversion luminescence for monitoring the therapeutic process.