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Spatially Gradated Hydrogel Platform as a 3D Engineered Tumor Microenvironment
Author(s) -
Pedron Sara,
Becka Eftalda,
Harley Brendan A.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404896
Subject(s) - glioblastoma , self healing hydrogels , materials science , microfluidics , tumor microenvironment , gelatin , biomaterial , glioma , nanotechnology , in situ , brain tumor , biocompatible material , biomedical engineering , tumor cells , cancer research , biology , pathology , chemistry , medicine , polymer chemistry , biochemistry , organic chemistry
There is an acute need for biomaterial tools that recreate the heterogeneous brain‐tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor‐inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.