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Tunable Rigidity of (Polymeric Core)–(Lipid Shell) Nanoparticles for Regulated Cellular Uptake
Author(s) -
Sun Jiashu,
Zhang Lu,
Wang Jiuling,
Feng Qiang,
Liu Dingbin,
Yin Qifang,
Xu Dongyan,
Wei Yujie,
Ding Baoquan,
Shi Xinghua,
Jiang Xingyu
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404788
Subject(s) - rigidity (electromagnetism) , materials science , nanoparticle , structural rigidity , membrane , nanotechnology , biophysics , chemical engineering , composite material , chemistry , biochemistry , geometry , mathematics , engineering , biology
Core–shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more‐rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity‐dependent cellular uptake is revealed through atomistic‐level simulations.