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Hexamodal Imaging with Porphyrin‐Phospholipid‐Coated Upconversion Nanoparticles
Author(s) -
Rieffel James,
Chen Feng,
Kim Jeesu,
Chen Guanying,
Shao Wei,
Shao Shuai,
Chitgupi Upendra,
Hernandez Reinier,
Graves Stephen A.,
Nickles Robert J.,
Prasad Paras N.,
Kim Chulhong,
Cai Weibo,
Lovell Jonathan F.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404739
Subject(s) - materials science , photon upconversion , nanoparticle , porphyrin , fluorescence , biocompatible material , fluorescence lifetime imaging microscopy , luminescence , preclinical imaging , nanotechnology , in vivo , tomography , optoelectronics , photochemistry , optics , biomedical engineering , chemistry , medicine , physics , microbiology and biotechnology , biology
Hexamodal imaging using simple nanoparticles is demonstrated. Porphyrin‐phospholipids are used to coat upconversion nanoparticles in order to generate a new biocompatible material. The nanoparticles are characterized in vitro and in vivo for imaging via fluorescence, upconversion, positron emission tomography, computed tomography, Cerenkov luminescence, and photoacoustic tomography.