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Peptide Assembly Integration of Fibroblast‐Targeting and Cell‐Penetration Features for Enhanced Antitumor Drug Delivery
Author(s) -
Ji Tianjiao,
Ding Yanping,
Zhao Ying,
Wang Jing,
Qin Hao,
Liu Xiaoman,
Lang Jiayan,
Zhao Ruifang,
Zhang Yinlong,
Shi Jian,
Tao Ning,
Qin Zhihai,
Nie Guangjun
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404715
Subject(s) - peptide , drug delivery , nanotechnology , internalization , targeted drug delivery , materials science , penetration (warfare) , fibroblast , cell , computational biology , cancer research , computer science , chemistry , biochemistry , medicine , biology , engineering , operations research , in vitro
An integrated cell‐penetrating peptide‐assembly‐based nanomaterial is engineered as a dual‐mode strategy for enhancing nanotherapeutic tumor targeting and penetration through recognition and depletion of cancer‐associated fibroblasts. The dual‐mode strategy is composed of cancer‐associated fibroblast‐specific antibody targeting for overcoming tissue barrier and cell‐penetration peptide‐mediated enhanced cellular uptake.