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A Fast and Activatable Cross‐Linking Strategy for Hydrogel Formation
Author(s) -
Jonker Anika M.,
Borrmann Annika,
van Eck Ernst R. H.,
van Delft Floris L.,
Löwik Dennis W. P. M.,
van Hest Jan C. M.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404448
Subject(s) - moiety , self healing hydrogels , sodium periodate , cycloaddition , periodate , materials science , combinatorial chemistry , quinone , nanotechnology , computer science , chemical engineering , polymer chemistry , chemistry , organic chemistry , catalysis , engineering
Strain‐promoted oxidation‐controlled cyclooctyne‐1,2‐quinone cycloaddition (SPOCQ) is a fast and activatable cross‐linking strategy for hydrogel formation. Gelation is induced by oxidation, which is performed both chemically using sodium periodate and enzymatically using mushroom tyrosinase. Due to the fast reaction kinetics, SPOCQ‐formed hydrogels can be functionalized in one‐pot with an azido‐containing moiety using SPAAC cross‐linking.