Premium
Large‐Pore Ultrasmall Mesoporous Organosilica Nanoparticles: Micelle/Precursor Co‐templating Assembly and Nuclear‐Targeted Gene Delivery
Author(s) -
Wu Meiying,
Meng Qingshuo,
Chen Yu,
Du Yanyan,
Zhang Lingxia,
Li Yaping,
Zhang Linlin,
Shi Jianlin
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404256
Subject(s) - materials science , nanotechnology , nanoparticle , micelle , gene delivery , mesoporous material , mesoporous silica , transfection , gene , chemistry , catalysis , organic chemistry , biochemistry , aqueous solution
A novel micelle/precursor co‐templating assembly strategy is successfully developed to synthesize large‐pore ultrasmall mesoporous organosilica nanoparticles (MONs). Furthermore, elaborately designed MONs with a cell‐penetrating peptide (TAT) (MONs–PTAT) are constructed for highly efficient intranuclear gene delivery. They exhibit a high loading capacity, improved protection for the loaded gene, and enhanced transfection efficiencies of EGFP plasmid (pEGFP).