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Generation of Novel Hybrid Aptamer–Molecularly Imprinted Polymeric Nanoparticles
Author(s) -
Poma Alessandro,
Brahmbhatt Heli,
Pendergraff Hannah M.,
Watts Jonathan K.,
Turner Nicholas W.
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404235
Subject(s) - aptamer , materials science , molecularly imprinted polymer , nanoparticle , nanotechnology , molecular imprinting , molecular recognition , monomer , polymer , molecule , selectivity , organic chemistry , chemistry , microbiology and biotechnology , composite material , biology , catalysis
A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.