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Core–Shell Pd@Au Nanoplates as Theranostic Agents for In‐Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy
Author(s) -
Chen Mei,
Tang Shaoheng,
Guo Zhide,
Wang Xiaoyong,
Mo Shiguang,
Huang Xiaoqing,
Liu Gang,
Zheng Nanfeng
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201404013
Subject(s) - photothermal therapy , materials science , biocompatibility , photoacoustic imaging in biomedicine , in vivo , nanotechnology , nanoshell , bimetallic strip , preclinical imaging , nanoparticle , biomedical engineering , tumor ablation , ablation , optics , medicine , metallurgy , biology , metal , physics , microbiology and biotechnology
Uniform plasmonic Pd@Au core–shell bimetallic nanoplates are synthesized by seeded growth strategy. Surface modified with SH‐PEG makes it good biocompatibility, prolonged blood circulation, and relatively high tumor accumulation. Enhanced tumor contrast effects can be obtained for in vivo photoacoustic/CT imaging after intravenous injection of Pd@Au‐PEG. Moreover, efficient photothermal tumor ablation is achieved, guided by the imaging techniques. This work promises further exploration of the superiority of 2D nanostructures for in vivo biomedical applications.