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A Multitheragnostic Nanobubble System to Induce Blood–Brain Barrier Disruption with Magnetically Guided Focused Ultrasound
Author(s) -
Huang HsinYang,
Liu HaoLi,
Hsu PoHung,
Chiang ChihSheng,
Tsai ChihHung,
Chi HueiShang,
Chen SanYuan,
Chen YouYin
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403889
Subject(s) - magnetic resonance imaging , drug delivery , ultrasound , materials science , blood–brain barrier , nanotechnology , neuroscience , biomedical engineering , computer science , central nervous system , medicine , radiology , biology
A novel magnetically guidable nanobubble is designed for disrupting the blood–brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic‐nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)‐induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual‐modality contrast‐agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.