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A Reduction and pH Dual‐Sensitive Polymeric Vector for Long‐Circulating and Tumor‐Targeted siRNA Delivery
Author(s) -
Li Jingguo,
Yu Xingsu,
Wang Yong,
Yuan Yuanyuan,
Xiao Hong,
Cheng Du,
Shuai Xintao
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403877
Subject(s) - nanomedicine , nanotechnology , endocytosis , materials science , dual (grammatical number) , biophysics , internalization , drug delivery , combinatorial chemistry , cancer research , nanoparticle , biochemistry , chemistry , biology , cell , art , literature
A novel reduction and pH dual‐sensitive nonviral vector for long‐circulating and tumor‐targeted siRNA delivery is described. The nanomedicine is negatively charged at neutral pH of bloodstream whereas it is positively charged at lower pH of tumor tissue (ca. 6.8). Interlayer crosslinking with disulfide bonds stabilizes the nanomedicine during blood circulation and allows quick intracellular siRNA release after endocytosis.