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Highly Fluorescent, Photostable, and Ultrasmall Silicon Drug Nanocarriers for Long‐Term Tumor Cell Tracking and In‐Vivo Cancer Therapy
Author(s) -
Ji Xiaoyuan,
Peng Fei,
Zhong Yiling,
Su Yuanyuan,
Jiang Xiangxu,
Song Chongxi,
Yang Liu,
Chu Binbin,
Lee ShuitTong,
He Yao
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403848
Subject(s) - nanocarriers , materials science , in vivo , nanotechnology , fluorescence , drug delivery , drug , nanoparticle , cancer research , medicine , pharmacology , biology , quantum mechanics , physics , microbiology and biotechnology
Silicon nanoparticle (SiNP) nanocarriers feature strong fluorescence, ultrasmall size, robust photostability, and tunable drug‐loading capacity. Using SiNP nanocarriers, the first example of long‐term cancer cell tracking is successfully demonstrated. Furthermore, in vivo experiments show that tumor‐bearing mice treated with SiNP nanocarriers survive over 20 d without observable tumor growth, demonstrating the high‐efficacy chemotherapy of the Si nanocarriers.