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Synthesis and Characterization of a Library of In‐Situ Curing, Nonswelling Ethoxylated Polyol Thiol‐ene Hydrogels for Tailorable Macromolecule Delivery
Author(s) -
O'Shea Timothy M.,
Aimetti Alex A.,
Kim Eunha,
Yesilyurt Volkan,
Langer Robert
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403724
Subject(s) - self healing hydrogels , materials science , polyol , biocompatibility , drug delivery , polyethylene glycol , click chemistry , macromolecule , thiol , polymer chemistry , nanotechnology , chemical engineering , organic chemistry , polyurethane , chemistry , composite material , biochemistry , engineering , metallurgy
A transesterfication reaction is used to synthesize tri‐thiol‐functionalized‐ethoxylated polyols that are combined with polyethylene glycol diacrylates to form a biodegradable hydrogel library. Hydrogels display nonswelling equilibration and offer temporal control over material degradation and the release of biomolecules. The demonstrated in vitro biocompatibility makes this a versatile platform that can be used for local drug delivery to volume‐constrained anatomical sites.