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Hybrid ZnO Nanorod‐Polymer Brush Hierarchically Nanostructured Substrate for Sensitive Antibody Microarrays
Author(s) -
Hu Weihua,
Liu Yingshuai,
Chen Tao,
Liu Yang,
Li Chang Ming
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403712
Subject(s) - materials science , nanorod , polymer brush , substrate (aquarium) , polymer , detection limit , nanotechnology , brush , adhesion , nanoscopic scale , chemical engineering , chromatography , composite material , polymerization , chemistry , oceanography , geology , engineering
A hierarchically nanostructured organic–inorganic hybrid substrate comprising randomly oriented ZnO nanorods on glass slide with coaxially tethered dense polymer brush, POEGMA‐ co ‐GMA is reported for highly sensitive antibody microassay, achieving excellent detection specificity, and superior detection limit of as low as 100 fg mL −1 for biomarkers in human serum within a 1 h assay time.