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Doxorubicin‐Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug‐Resistant Cancer
Author(s) -
Tian Ye,
Jiang Xuejiao,
Chen Xin,
Shao Zhengzhong,
Yang Wuli
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403562
Subject(s) - fibroin , materials science , magnetic nanoparticles , doxorubicin , nanotechnology , nanoparticle , drug delivery , cancer therapy , nanometre , silk , cancer , chemotherapy , composite material , medicine , surgery
A strategy to prepare doxorubicin‐loaded magnetic silk fibroin nanoparticles is presented. The nanoparticles serve as a nanometer‐scale drug‐delivery system in the chemotherapy of multidrug‐resistant cancer under the guidance of a magnetic field. The magnetic tumor‐targeting ability broadens the range of biomedical applications of silk fibroin, and the nanoparticle‐assisted preparation strategy is useful for the advancement of other biomacromolecule‐based materials.