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Molecular‐Dynamics‐Simulation‐Driven Design of a Protease‐Responsive Probe for In‐Vivo Tumor Imaging
Author(s) -
Jiang Yifan,
Lu Junyan,
Wang Yaping,
Zeng Feng,
Wang Huiyuan,
Peng Huige,
Huang Min,
Jiang Hualiang,
Luo Cheng,
Huang Yongzhuo
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403547
Subject(s) - förster resonance energy transfer , rational design , materials science , in vivo , molecular dynamics , protease , carcinogenesis , nanotechnology , biophysics , energy transfer , cancer , fluorescence , biology , biochemistry , enzyme , chemistry , chemical physics , physics , microbiology and biotechnology , computational chemistry , genetics , quantum mechanics
A protease‐responsive probe is developed based on a molecular dynamics simulation method for the rational design of the hairpin “turn” structure of peptides. The Förster resonance energy transfer (FRET)‐based probe is used for in vivo detection of legumain, a protease overexpressed in inflammation‐related carcinogenesis, providing a potential method for early cancer detection and tumor imaging, and helpful information for better understanding legumain's role in tumorigenesis.