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Aptamer‐Functionalized Barcode Particles for the Capture and Detection of Multiple Types of Circulating Tumor Cells
Author(s) -
Zheng Fuyin,
Cheng Yao,
Wang Jie,
Lu Jie,
Zhang Bin,
Zhao Yuanjin,
Gu Zhongze
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403530
Subject(s) - aptamer , materials science , barcode , surface modification , dendrimer , nanotechnology , circulating tumor cell , nanoparticle , colloidal particle , colloidal gold , colloid , biophysics , microbiology and biotechnology , cancer , computer science , chemical engineering , biology , polymer chemistry , genetics , engineering , metastasis , operating system
Aptamer‐functionalized barcode particles are employed to capture and detect various types of circulating tumor cells (CTCs). The particles are spherical colloidal crystal clusters, and the reflection properties that arise from their structures are how their codes are evaluated. Aptamer functionalization (with TD05, Sgc8, and Sgd5) make the particles interact with specific CTC types; dendrimers are used to amplify the effect of the aptamers, allowing for increased sensitivity, reliability, and specificity in CTC capture, detection, and subsequent release.