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Two‐Photon Excitation of Porphyrin‐Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy
Author(s) -
Secret Emilie,
Maynadier Marie,
Gallud Audrey,
Chaix Arnaud,
Bouffard Elise,
GaryBobo Magali,
Marcotte Nathalie,
Mongin Olivier,
El Cheikh Khaled,
Hugues Vincent,
Auffan Mélanie,
Frochot Céline,
Morère Alain,
Maillard Philippe,
BlanchardDesce Mireille,
Sailor Michael J.,
Garcia Marcel,
Durand JeanOlivier,
Cunin Frédérique
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403415
Subject(s) - photodynamic therapy , porphyrin , materials science , porous silicon , nanoparticle , two photon excitation microscopy , mannose receptor , endocytosis , nanotechnology , excitation , silicon , photon , photochemistry , optoelectronics , optics , cell , chemistry , organic chemistry , biochemistry , physics , engineering , macrophage , electrical engineering , in vitro
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2‐photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose‐functionalized pSiNPs can be vectorized to MCF‐7 human breast cancer cells through a mannose receptor‐mediated endocytosis mechanism to provide a 3‐fold enhancement of the 2‐photon PDT effect.