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Gram‐Positive Antimicrobial Activity of Amino Acid‐Based Hydrogels
Author(s) -
Irwansyah I.,
Li YongQiang,
Shi Wenxiong,
Qi Dianpeng,
Leow Wan Ru,
Tang Mark B. Y.,
Li Shuzhou,
Chen Xiaodong
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403339
Subject(s) - antimicrobial , self healing hydrogels , biocompatible material , nanotechnology , antimicrobial peptides , materials science , combinatorial chemistry , phenylalanine , amino acid , chemistry , biochemistry , organic chemistry , polymer chemistry , biomedical engineering , engineering
Antimicrobial hydrogels are prepared based on the co‐assembly of commercial Fmoc‐phenylalanine and Fmoc‐leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co‐assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram‐positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti‐infective applications.