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Scalable Units for Building Cardiac Tissue
Author(s) -
Ye Xiaofeng,
Lu Liang,
Kolewe Martin E.,
Hearon Keith,
Fischer Kristin M.,
Coppeta Jonathan,
Freed Lisa E.
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201403074
Subject(s) - materials science , scalability , elastomer , biomedical engineering , tissue engineering , in vivo , stacking , porosity , nanotechnology , computer science , composite material , engineering , biology , chemistry , database , microbiology and biotechnology , organic chemistry
Scalable units for building cardiac tissue are fabricated from biodegradable elastomeric polymers by pairwise stacking of heart‐cell scaffolds with sinusoidal internal pore architectures and dedicated perfusable microvessels with rapidly degrading porous interfaces in a parallel flow configuration. This platform supports viable heart cells in vitro and, if validated in vivo, may aid in the regenerative repair of vascularized tissues.