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Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti‐CTLA‐4 Therapy to Inhibit Cancer Metastasis
Author(s) -
Wang Chao,
Xu Ligeng,
Liang Chao,
Xiang Jian,
Peng Rui,
Liu Zhuang
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201402996
Subject(s) - photothermal therapy , carbon nanotube , materials science , tumor ablation , immune system , cancer , cancer research , cancer therapy , metastasis , cancer cell , ablation , nanotechnology , medicine , immunology
Photothermal ablation of primary tumors with single‐walled carbon nanotubes is demonstrated to be able to trigger significant adaptive immune responses, which are not observed if tumors are removed by surgical resection. Such a treatment in combination with anti‐CTLA‐4 antibody therapy is able to prevent the development of tumor metastasis, which is a major cause of cancer death.