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Break‐up of Two‐Dimensional MnO 2 Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer
Author(s) -
Chen Yu,
Ye Delai,
Wu Meiying,
Chen Hangrong,
Zhang Linlin,
Shi Jianlin,
Wang Lianzhou
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201402572
Subject(s) - materials science , polyethylene glycol , in vivo , nanotechnology , cancer cell , tumor microenvironment , cancer , in vitro , biophysics , drug delivery , multiple drug resistance , chemistry , biochemistry , biology , genetics , microbiology and biotechnology , antibiotics
Chemically exfoliated two‐dimensional MnO 2 nanosheets are successfully modified with amino‐polyethylene glycol as a theranostic platform for ultrasensitive stimuli‐responsive theranostics of cancer. The highly dispersed MnO 2 nanosheets exhibit a unique break‐up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T 1 ‐weighted magnetic resonance imaging. Such a pH‐triggered breaking‐up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH‐responsive drug release and circumvent the multidrug resistance of cancer cells.