Break‐up of Two‐Dimensional MnO 2  Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer | Zendy

Chen Yu | Zendy; Ye Delai | Zendy; Wu Meiying | Zendy; Chen Hangrong | Zendy; Zhang Linlin | Zendy; Shi Jianlin | Zendy; Wang Lianzhou | Zendy

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Break‐up of Two‐Dimensional MnO 2 Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer

Author(s) -

Chen Yu,

Ye Delai,

Wu Meiying,

Chen Hangrong,

Zhang Linlin,

Shi Jianlin,

Wang Lianzhou

Publication year - 2014

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201402572

Subject(s) - materials science , polyethylene glycol , in vivo , nanotechnology , cancer cell , tumor microenvironment , cancer , in vitro , biophysics , drug delivery , multiple drug resistance , chemistry , biochemistry , biology , genetics , microbiology and biotechnology , antibiotics

Chemically exfoliated two‐dimensional MnO 2 nanosheets are successfully modified with amino‐polyethylene glycol as a theranostic platform for ultrasensitive stimuli‐responsive theranostics of cancer. The highly dispersed MnO 2 nanosheets exhibit a unique break‐up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T 1 ‐weighted magnetic resonance imaging. Such a pH‐triggered breaking‐up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH‐responsive drug release and circumvent the multidrug resistance of cancer cells.

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