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Multifunctional “Smart” Particles Engineered from Live Immunocytes: Toward Capture and Release of Cancer Cells
Author(s) -
Huang Chao,
Yang Gao,
Ha Qing,
Meng Jinxin,
Wang Shutao
Publication year - 2015
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201402213
Subject(s) - materials science , cancer cell , nanotechnology , disulfide bond , biophysics , cancer , biology , biochemistry , genetics
Multifunctional “smart” particles with magnetic, topographic, cell‐targeting, and stimulus‐responsive properties are obtained using a “live template” strategy. These particles exhibit improved efficiency in capture of target cancer cells by introducing synergistic topographic interactions, and enable the release of captured cells with high viability via reduction of disulfide bonds. Diverse multifunctional particles can be designed using the “live template” strategy.