Cationic Oligo(p‐phenylene vinylene) Materials for Combating Drug Resistance of Cancer Cells by Light Manipulation | Zendy

Wang Bing | Zendy; Yuan Huanxiang | Zendy; Liu Zhang | Zendy; Nie Chenyao | Zendy; Liu Libing | Zendy; Lv Fengting | Zendy; Wang Yilin | Zendy; Wang Shu | Zendy

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Cationic Oligo(p‐phenylene vinylene) Materials for Combating Drug Resistance of Cancer Cells by Light Manipulation

Author(s) -

Wang Bing,

Yuan Huanxiang,

Liu Zhang,

Nie Chenyao,

Liu Libing,

Lv Fengting,

Wang Yilin,

Wang Shu

Publication year - 2014

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201402183

Subject(s) - photosensitizer , materials science , cancer cell , drug , cationic polymerization , drug resistance , nanotechnology , drug delivery , cancer , biophysics , pharmacology , chemistry , biology , organic chemistry , microbiology and biotechnology , polymer chemistry , genetics

An unconventional strategy that can be temporally and remotely activated with light to combat the drug resistance of cancer cells is developed. A cell‐membrane‐anchored photosensitizer (OPV) is used to enhance anticancer drug uptake and restore toxicity in resistant cancer cells. This method recovers the activity of the already established anticancer drugs, and provides a new strategy for the development of light manipulation to combat anticancer resistance.

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