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Cationic Oligo(p‐phenylene vinylene) Materials for Combating Drug Resistance of Cancer Cells by Light Manipulation
Author(s) -
Wang Bing,
Yuan Huanxiang,
Liu Zhang,
Nie Chenyao,
Liu Libing,
Lv Fengting,
Wang Yilin,
Wang Shu
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201402183
Subject(s) - photosensitizer , materials science , cancer cell , drug , cationic polymerization , drug resistance , nanotechnology , drug delivery , cancer , biophysics , pharmacology , chemistry , biology , organic chemistry , microbiology and biotechnology , polymer chemistry , genetics
An unconventional strategy that can be temporally and remotely activated with light to combat the drug resistance of cancer cells is developed. A cell‐membrane‐anchored photosensitizer (OPV) is used to enhance anticancer drug uptake and restore toxicity in resistant cancer cells. This method recovers the activity of the already established anticancer drugs, and provides a new strategy for the development of light manipulation to combat anticancer resistance.