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Biodegradable Ethylene‐Bis(Propyl)Disulfide‐Based Periodic Mesoporous Organosilica Nanorods and Nanospheres for Efficient In‐Vitro Drug Delivery
Author(s) -
Croissant Jonas,
Cattoën Xavier,
Man Michel Wong Chi,
Gallud Audrey,
Raehm Laurence,
Trens Philippe,
Maynadier Marie,
Durand JeanOlivier
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201401931
Subject(s) - materials science , nanorod , mesoporous organosilica , drug delivery , nanoparticle , nanotechnology , doxorubicin , nanostructure , mesoporous material , mesoporous silica , organic chemistry , chemistry , catalysis , medicine , surgery , chemotherapy
Periodic mesoporous organosilica nanorods and nanospheres are synthesized from 1,4‐bis(triethoxysilyl)ethylene and bis(3‐ethoxysilylpropyl)disulfide. The nanosystems present the long‐range order of the hexagonal nanostructure. They are degraded in simulated physiological conditions. The loading and release of doxorubicin with these nanosystems are both pH dependent. These nanoparticles are endocytosed by breast cancer cells and are very efficient for doxorubicin delivery in these cells.