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Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs
Author(s) -
Sun Qihang,
Sun Xuanrong,
Ma Xinpeng,
Zhou Zhuxian,
Jin Erlei,
Zhang Bo,
Shen Youqing,
Van Kirk Edward A.,
Murdoch William J.,
Lott Joseph R.,
Lodge Timothy P.,
Radosz Maciej,
Zhao Yuliang
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201401554
Subject(s) - dendrimer , materials science , nanotechnology , internalization , drug delivery , drug , cascade , nanoparticle , cancer , cancer research , cell , pharmacology , chemistry , medicine , biochemistry , chromatography , polymer chemistry
A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like “bomblets”, enabling tumor penetration, cell internalization, and drug release.