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Stem Cells Loaded with Nanoparticles as a Drug Carrier for In Vivo Breast Cancer Therapy
Author(s) -
Cao Binrui,
Yang Mingying,
Zhu Ye,
Qu Xuewei,
Mao Chuanbin
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201401550
Subject(s) - photosensitizer , photodynamic therapy , mesenchymal stem cell , in vivo , breast cancer , materials science , cancer research , drug , nanoparticle , drug delivery , cancer therapy , cancer , biomedical engineering , nanotechnology , medicine , pharmacology , pathology , chemistry , biology , microbiology and biotechnology , organic chemistry
A novel anti‐cancer drug carrier , mesenchymal stem cells (MSCs) encapsulating drug‐loaded hollow silica nanoparticles, is used to carry a photosensitizer drug and deliver it to breast tumors, due to the natural high tumor affinity of the MSCs, and inhibit tumor growth by photo dynamic therapy. This new strategy for delivering a photo sensitizer to tumors by using tumor‐affinitive MSCs addresses the challenge of the accumulation of photosensitizer drugs in tumors in photodynamic therapy.