Premium
Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity
Author(s) -
Kwon Koo Chul,
Ryu Ju Hee,
Lee JongHwan,
Lee Eun Jung,
Kwon Ick Chan,
Kim Kwangmeyung,
Lee Jeewon
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201401499
Subject(s) - photothermal therapy , materials science , colloidal gold , nanotechnology , cancer therapy , nanomedicine , nanotoxicology , in vivo , nanoparticle , core (optical fiber) , cancer , biophysics , biology , microbiology and biotechnology , composite material , genetics
PGCS‐NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1–3 nm) are densely presented. The IV‐injected PGCS‐NPs into EGFR‐expressing tumor‐bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS‐NPs are easily removed and never cause in vivo toxicity problems.