Intrinsically Germanium‐69‐Labeled Iron Oxide Nanoparticles: Synthesis and In‐Vivo Dual‐Modality PET/MR Imaging | Zendy

Chakravarty Rubel | Zendy; Valdovinos Hector F. | Zendy; Chen Feng | Zendy; Lewis Christina M. | Zendy; Ellison Paul A. | Zendy; Luo Haiming | Zendy; Meyerand M. Elizabeth | Zendy; Nickles Robert J. | Zendy; Cai Weibo | Zendy

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Intrinsically Germanium‐69‐Labeled Iron Oxide Nanoparticles: Synthesis and In‐Vivo Dual‐Modality PET/MR Imaging

Author(s) -

Chakravarty Rubel,

Valdovinos Hector F.,

Chen Feng,

Lewis Christina M.,

Ellison Paul A.,

Luo Haiming,

Meyerand M. Elizabeth,

Nickles Robert J.,

Cai Weibo

Publication year - 2014

Publication title -

advanced materials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 10.707

H-Index - 527

eISSN - 1521-4095

pISSN - 0935-9648

DOI - 10.1002/adma.201401372

Subject(s) - materials science , positron emission tomography , magnetic resonance imaging , germanium , biodistribution , in vivo , modality (human–computer interaction) , nanoparticle , preclinical imaging , nuclear magnetic resonance , biomedical engineering , nanotechnology , nuclear medicine , radiology , medicine , computer science , optoelectronics , physics , microbiology and biotechnology , human–computer interaction , biology , silicon

Intrinsically germanium‐69‐labeled super‐paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator‐free approach. The biodistribution pattern and the feasibility of 69 Ge‐SPION@PEG for in vivo dual‐modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph‐node mapping are investigated, which represents the first example of the successful utilization of a 69 Ge‐based agent for PET/MR imaging.

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