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Intrinsically Germanium‐69‐Labeled Iron Oxide Nanoparticles: Synthesis and In‐Vivo Dual‐Modality PET/MR Imaging
Author(s) -
Chakravarty Rubel,
Valdovinos Hector F.,
Chen Feng,
Lewis Christina M.,
Ellison Paul A.,
Luo Haiming,
Meyerand M. Elizabeth,
Nickles Robert J.,
Cai Weibo
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201401372
Subject(s) - materials science , positron emission tomography , magnetic resonance imaging , germanium , biodistribution , in vivo , modality (human–computer interaction) , nanoparticle , preclinical imaging , nuclear magnetic resonance , biomedical engineering , nanotechnology , nuclear medicine , radiology , medicine , computer science , optoelectronics , physics , microbiology and biotechnology , human–computer interaction , biology , silicon
Intrinsically germanium‐69‐labeled super‐paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator‐free approach. The biodistribution pattern and the feasibility of 69 Ge‐SPION@PEG for in vivo dual‐modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph‐node mapping are investigated, which represents the first example of the successful utilization of a 69 Ge‐based agent for PET/MR imaging.