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Bio‐Inspired Cryo‐Ink Preserves Red Blood Cell Phenotype and Function During Nanoliter Vitrification
Author(s) -
El Assal Rami,
Guven Sinan,
Gurkan Umut Atakan,
Gozen Irep,
Shafiee Hadi,
Dalbeyler Sedef,
Abdalla Noor,
Thomas Gawain,
Fuld Wendy,
Illigens Ben M. W.,
Estanislau Jessica,
Khoory Joseph,
Kaufman Richard,
Zylberberg Claudia,
Lindeman Neal,
Wen Qi,
Ghiran Ionita,
Demirci Utkan
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201400941
Subject(s) - vitrification , cryopreservation , materials science , cell function , function (biology) , nanotechnology , red blood cell , biophysics , cell , microbiology and biotechnology , biology , embryo , immunology , andrology , genetics , medicine
Current red‐blood‐cell cryopreservation methods utilize bulk volumes, causing cryo‐injury of cells, which results in irreversible disruption of cell morphology, mechanics, and function. An innovative approach to preserve human red‐blood‐cell morphology, mechanics, and function following vitrification in nanoliter volumes is developed using a novel cryo‐ink integrated with a bioprinting approach.