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A Novel Poly(amido amine)‐Dendrimer‐Based Hydrogel as a Mimic for the Extracellular Matrix
Author(s) -
Wang Yao,
Zhao Qiang,
Zhang He,
Yang Sheng,
Jia Xinru
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201400323
Subject(s) - dendrimer , extracellular matrix , materials science , self healing hydrogels , tissue engineering , drug delivery , nanotechnology , computer science , biomedical engineering , polymer chemistry , microbiology and biotechnology , biology , engineering
The extracellular matrix is mimicked by a novel dendrimer‐based hydrogel, which exhibits a highly interconnected porous network, enhanced mechanical stiffness, and a low swelling ratio. The hydrogel system supports the proliferation and differentiation of mesenchymal stem cells without any cytotoxic effects. This dendrimer‐based hydrogel may serve as a model for developing new advanced materials with applications in tissue engineering.