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Multifunctional Theranostic Red Blood Cells For Magnetic‐Field‐Enhanced in vivo Combination Therapy of Cancer
Author(s) -
Wang Chao,
Sun Xiaoqi,
Cheng Liang,
Yin Shengnan,
Yang Guangbao,
Li Yonggang,
Liu Zhuang
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201400158
Subject(s) - nanotechnology , drug delivery , biocompatible material , doxorubicin , materials science , photodynamic therapy , photosensitizer , in vivo , cancer therapy , cancer treatment , blood cancer , cancer chemotherapy , cancer , computer science , biomedical engineering , chemotherapy , medicine , chemistry , microbiology and biotechnology , biology , surgery , organic chemistry
Red blood cells are attached to iron oxide nanoparticles pre‐coated with chlorine e6, a photosensitizer, and then loaded with a chemotherapeutic drug, doxorubicin, to enable imaging‐guided combined photodynamic and chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise of integrating cell‐based drug‐delivery systems with nanotechnology as a biocompatible multifunctional platform for applications in cancer theranostics.