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Phage Nanofibers Induce Vascularized Osteogenesis in 3D Printed Bone Scaffolds
Author(s) -
Wang Jianglin,
Yang Mingying,
Zhu Ye,
Wang Lin,
Tomsia Antoni P.,
Mao Chuanbin
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201400154
Subject(s) - library science , research center , biological sciences , chinese academy of sciences , chemistry , polymer science , engineering , china , biology , computer science , medicine , archaeology , history , computational biology , pathology
A virus‐activated matrix is developed to overcome the challenge of forming vascularized bone tissue. It is generated by filling a 3D printed bioceramic scaffold with phage nanofibers displaying high‐density RGD peptide. After it is seeded with mesenchymal stem cells (MSCs) and implanted into a bone defect, the phage nanofibers induce osteogenesis and angiogenesis by activating endothelialization and osteogenic differentiation of MSCs.