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Nanoparticles: Nanoparticles Mimicking Viral Surface Topography for Enhanced Cellular Delivery (Adv. Mater. 43/2013)
Author(s) -
Niu Yuting,
Yu Meihua,
Hartono Sandy B.,
Yang Jie,
Xu Hongyi,
Zhang Hongwei,
Zhang Jun,
Zou Jin,
Dexter Annette,
Gu Wenyi,
Yu Chengzhong
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201370274
Subject(s) - nanoparticle , materials science , biomolecule , nanotechnology , drug delivery , rational design , surface modification , biophysics , chemical engineering , biology , engineering
A new strategy to synthesize nanoparticles with enhanced cellular delivery efficiency is presented by Chengzhong Yu and co‐workers on page 6233. Silica nanoparticles mimicking virus surface topography exhibit increased cellular uptake performance and improved binding capacity towards biomolecules (e.g., genetic molecules, proteins); thus the cellular delivery performance can be improved. This understanding is important in the rational design of new cellular delivery vectors for a range of bioapplications.