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Scaffolds: 3D Structural Patterns in Scalable, Elastomeric Scaffolds Guide Engineered Tissue Architecture (Adv. Mater. 32/2013)
Author(s) -
Kolewe Martin E.,
Park Hyoungshin,
Gray Caprice,
Ye Xiaofeng,
Langer Robert,
Freed Lisa E.
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201370200
Subject(s) - materials science , scaffold , elastomer , layer (electronics) , tissue engineering , biomedical engineering , nanotechnology , composite material , engineering
Microfabricated biodegradable scaffolds with 3D structural patterns are created by semi‐automated layer‐by‐layer assembly of elastomeric polymer sheets with through‐pores, as described by Lisa E. Freed and co‐workers on page 4459 . The 3D pore network architecture defined by the relative alignment of layers directed cell and muscle‐like fiber orientation in skeletal and cardiac muscle. In this picture, heart cell bundles weave through a pore network created in a multi‐layer poly(glycerol sebacate) (PGS) scaffold.