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Non‐Viral Gene Delivery via Membrane‐Penetrating, Mannose‐Targeting Supramolecular Self‐Assembled Nanocomplexes (Adv. Mater. 22/2013)
Author(s) -
Yin Lichen,
Song Ziyuan,
Kim Kyung Hoon,
Zheng Nan,
Gabrielson Nathan P.,
Cheng Jianjun
Publication year - 2013
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201370148
Subject(s) - internalization , endocytosis , mannose receptor , endosome , gene delivery , transduction (biophysics) , transfection , materials science , mannose , supramolecular chemistry , nanotechnology , microbiology and biotechnology , biophysics , gene , chemistry , biology , cell , biochemistry , intracellular , in vitro , macrophage , crystal structure , crystallography
Supramolecular self‐assembled nanocomplexes allow mannose receptormediated endocytosis and mediate membrane transduction via the pore formation mechanism, which facilitates effective cellular internalization and endosomal escape towards highly effective gene transfection, as reported by Jianjun Cheng and co‐workers on page 3063 .