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Integrating Oxaliplatin with Highly Luminescent Carbon Dots: An Unprecedented Theranostic Agent for Personalized Medicine
Author(s) -
Zheng Min,
Liu Shi,
Li Jing,
Qu Dan,
Zhao Haifeng,
Guan Xingang,
Hu Xiuli,
Xie Zhigang,
Jing Xiabin,
Sun Zaicheng
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201306192
Subject(s) - oxaliplatin , nanomedicine , nanotechnology , drug delivery , materials science , tracking (education) , function (biology) , fluorescence , computer science , combinatorial chemistry , cancer , medicine , nanoparticle , chemistry , physics , biology , psychology , colorectal cancer , quantum mechanics , pedagogy , evolutionary biology
A theranostic nanomedicine (CD‐Oxa) is synthesized by means of the condensation reaction between the amino groups on the surface of fluorescent carbon dots (CDs) and the carboxyl group of the oxaliplatin derivative Oxa(IV)‐COOH. CD‐Oxa, which integrates the optical properties of CDs and the anticancer function of oxaliplatin, could be used for simultaneous drug delivery and fluorescent tracking.