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Spatiotemporally Controllable and Cytocompatible Approach Builds 3D Cell Culture Matrix by Photo‐Uncaged‐Thiol Michael Addition Reaction
Author(s) -
Liu Zhenzhen,
Lin Qiuning,
Sun Yun,
Liu Tao,
Bao Chunyan,
Li Fuyou,
Zhu Linyong
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201306061
Subject(s) - michael reaction , materials science , matrix (chemical analysis) , regenerative medicine , thiol , nanotechnology , biophysics , cell , chemistry , biology , catalysis , organic chemistry , biochemistry , composite material
A new concept of photocrosslinking mechanism is developed to construct a 3D cell culture matrix based on a photo‐uncaged‐thiol Michael addition. This first‐class approach not only provides highly cytocompatible gelation in a spatiotemporally controlled manner, but also controls gel stiffness via appropriate light dose, signaling desired cues to live cells and thus important to bioengineering and regenerative medicine.