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Rational Design of Synthetic Nanoparticles with a Large Reversible Shift of Acid Dissociation Constants: Proton Imprinting in Stimuli Responsive Nanogel Particles
Author(s) -
Hoshino Yu,
Ohashi Ryohei C.,
Miura Yoshiko
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201305957
Subject(s) - nanogel , monomer , materials science , dissociation (chemistry) , polymerization , nanoparticle , nanotechnology , imprinting (psychology) , rational design , combinatorial chemistry , polymer , computer science , drug delivery , chemistry , organic chemistry , biochemistry , composite material , gene
Temperature‐responsive nanogel particles with acids exhibiting large and reversible p K a shift are prepared by an ion‐imprinting polymerization of stimuli responsive monomers, cross‐linkers, and acidic monomers using protons as a template. The principles employed here should be broadly applicable to other stimuli‐responsive materials and will be an integral step in the production of active proton transporter.