Premium
Microfluidic‐Assisted Self‐Assembly of Complex Dendritic Polyethylene Drug Delivery Nanocapsules
Author(s) -
HasaniSadrabadi Mohammad Mahdi,
Karimkhani Vahid,
Majedi Fatemeh Sadat,
Van Dersarl Jules John,
Dashtimoghadam Erfan,
AfsharTaromi Faramarz,
Mirzadeh Hamid,
Bertsch Arnaud,
Jacob Karl I.,
Renaud Philippe,
Stadler Florian J.,
Kim Il
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201305753
Subject(s) - nanocapsules , materials science , nanocarriers , nanotechnology , dispersity , microfluidics , drug delivery , copolymer , paclitaxel , self assembly , poloxamer , nanoparticle , polymer , polymer chemistry , composite material , medicine , surgery , chemotherapy
Microfluidic platform for the synthesis of complex nanocapsules is presented via a controlled self‐assembly. The monodisperse nanocapsules in the range of 50–200 nm consist of a dendritic polyethylene core and a Pluronic copolymer shell. The resultant nanocarriers encapsulate large amount of hydrophobic anticancer drug like paclitaxel while providing a low complement activation as well as sustained release profile with high tunability.