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Ultrasmall NaGdF 4 Nanodots for Efficient MR Angiography and Atherosclerotic Plaque Imaging
Author(s) -
Xing Huaiyong,
Zhang Shengjian,
Bu Wenbo,
Zheng Xiangpeng,
Wang Lijun,
Xiao Qingfeng,
Ni Dalong,
Zhang Jiamin,
Zhou Liangping,
Peng Weijun,
Zhao Kuaile,
Hua Yanqing,
Shi Jianlin
Publication year - 2014
Publication title -
advanced materials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 10.707
H-Index - 527
eISSN - 1521-4095
pISSN - 0935-9648
DOI - 10.1002/adma.201305222
Subject(s) - nanodot , materials science , angiography , value (mathematics) , nanotechnology , medical physics , computer science , biomedical engineering , radiology , medicine , machine learning
Herein, ultrasmall NaGdF 4 nanodots (~2 nm) with DTPA conjugation have been synthesized for efficient MR angiography. Impressively, the r 1 value in MRI reaches up to 8.93 mM −1 ·s −1 . The ultrasmall vessel lumen of a rabbit is lighted up remarkably. After 3 h, atherosclerotic plaques could be discriminated clearly. This is beneficial for the accurate early diagnosis of vascular pathema.